| First Author | Liu X | Year | 2019 |
| Journal | Sci Rep | Volume | 9 |
| Issue | 1 | Pages | 10656 |
| PubMed ID | 31337812 | Mgi Jnum | J:285954 |
| Mgi Id | MGI:6387391 | Doi | 10.1038/s41598-019-46933-y |
| Citation | Liu X, et al. (2019) Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis. Sci Rep 9(1):10656 |
| abstractText | The Muc-1 oncoprotein is a tumor-associated mucin often overexpressed in pancreatic cancer. We report that knockout of Muc-1 reduced the degree of pancreatic inflammation that resulted from infection with Coxsackievirus B3 (CVB3) in a mouse model. CVB3-infected Muc-1-deficient (Muc-1(KO)) mice had significantly reduced infiltration of macrophages into the murine pancreas. We found that Muc-1 signaling through NF-kappaB increased expression of ICAM-1, a pro-inflammatory mediator that recruits macrophages. Further investigation revealed that bone marrow derived macrophages (BMDM) from the Muc-1(KO) mice exhibited defective migration properties, in part due to low expression of the C-C motif chemokine receptor (CCR2) and the integrin Very Late Antigen 4 (VLA-4). The results presented here provide novel insight into the role of Muc-1 in regulating the inflammatory response and the cellular microenvironment in pancreatitis. |
