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Protein Domain : E3 ubiquitin-protein ligase RNF31-like

Primary Identifier  IPR026254 Type  Family
Short Name  RNF31-like
description  RNF31 is a component of the linear ubiquitin chain assembly complex (LUBAC) [, , ]. RNF31 is also known as HOIL-1L interacting protein (HOIP). It has been shown that RNF31 interacts with the muscle-specific kinase (MuSK) in mice [].LUBAC catalyses the formation of linear ubiquitin chains and regulates immune and apoptopic signaling pathways [, , ]. LUBAC consists of SHARPIN, HOIL-1 (also known as RBCK1) and HOIP [, ].This family also includes the fly E3 ubiquitin-protein ligase lubel, which conjugates linear 'Met-1'- and 'Lys-63'-linked polyubiquitin chains to substrates. Ithas been shown to play a role in heat-stress response [], as well as being involved in the NF-kappa-B intestinal inflammatory response to oral infection in Drosophila [].

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0 Parent Features

11 Protein Domain Regions