Primary Identifier | IPR026254 | Type | Family |
Short Name | RNF31-like |
description | RNF31 is a component of the linear ubiquitin chain assembly complex (LUBAC) [, , ]. RNF31 is also known as HOIL-1L interacting protein (HOIP). It has been shown that RNF31 interacts with the muscle-specific kinase (MuSK) in mice [].LUBAC catalyses the formation of linear ubiquitin chains and regulates immune and apoptopic signaling pathways [, , ]. LUBAC consists of SHARPIN, HOIL-1 (also known as RBCK1) and HOIP [, ].This family also includes the fly E3 ubiquitin-protein ligase lubel, which conjugates linear 'Met-1'- and 'Lys-63'-linked polyubiquitin chains to substrates. Ithas been shown to play a role in heat-stress response [], as well as being involved in the NF-kappa-B intestinal inflammatory response to oral infection in Drosophila []. |