Primary Identifier | MGI:2441659 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 239739 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to be involved in several processes, including negative regulation of proteasomal protein catabolic process; regulation of autophagy; and response to interferon-alpha. Predicted to act upstream of or within adaptive immune response. Located in alveolar lamellar body membrane and lysosomal membrane. Is expressed in alveolus epithelium and lung. Orthologous to human LAMP3 (lysosomal associated membrane protein 3). PHENOTYPE: Under basal conditions, homozygous null mice display altered protein and lipid composition of pulmonary surfactant but normal viability and lung function. However, under conditions of experimental allergic asthma, mice show increased airway resistance and aggravated changes in BAL lipid composition. [provided by MGI curators] |