| First Author | Rosenberg YJ | Year | 1984 |
| Journal | J Immunol | Volume | 132 |
| Issue | 3 | Pages | 1261-4 |
| PubMed ID | 6607282 | Mgi Jnum | J:7302 |
| Mgi Id | MGI:55773 | Doi | 10.4049/jimmunol.132.3.1261 |
| Citation | Rosenberg YJ, et al. (1984) Influence of Y and X chromosomes on B cell responses in autoimmune prone mice. J Immunol 132(3):1261-4 |
| abstractText | BXSB mice, unlike other autoimmune strains, carry a Y chromosome-linked gene for accelerated autoimmunity, reflected by early onset disease in male but not female animals. To investigate whether the Y chromosome factor acts through other autosomal genes or is in itself sufficient for early disease, partially inbred congenic NZB.BXSB and NZW.BXSB mice were developed and studied for levels of Ig-secreting cells (IgFC) as a measure of their autoimmune state. In such mice, the BXSB contributed only the male chromosome and 3% of the autosomal genes. The results indicate that for full expression of autoimmunity, both the Y chromosome and one or more BXSB autosomal genes are required. In addition, the presence of the CBA/N xid gene results in a total reversal of any Y-linked effects. |
