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Publication : Cloning, functional expression and tissue distribution of rabbit alpha 1d-adrenoceptor.

First Author  Suzuki F Year  1997
Journal  Biochim Biophys Acta Volume  1323
Issue  1 Pages  6-11
PubMed ID  9030207 Mgi Jnum  J:37890
Mgi Id  MGI:85286 Doi  10.1016/s0005-2736(96)00229-5
Citation  Suzuki F, et al. (1997) Cloning, functional expression and tissue distribution of rabbit alpha 1d-adrenoceptor. Biochim Biophys Acta 1323(1):6-11
abstractText  We have cloned a cDNA encoding rabbit alpha 1d-adrenoceptor from the rabbit liver cDNA library. The deduced amino-acid sequence of this clone encodes a protein of 576 amino acids that shows strong sequence homology to previously cloned human, rat and mouse alpha 1d-adrenoceptors. The pharmacological radioligand binding properties of this clone expressed in COS-7 cells were similar to those of rat alpha 1d-adrenoceptors. Competitive RT/PCR assays revealed wide tissue distribution of the alpha 1d-adrenoceptor mRNA in rabbit, especially abundant in vas deferens, aorta, prostate and cerebral cortex.
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