First Author | Suzuki F | Year | 1997 |
Journal | Biochim Biophys Acta | Volume | 1323 |
Issue | 1 | Pages | 6-11 |
PubMed ID | 9030207 | Mgi Jnum | J:37890 |
Mgi Id | MGI:85286 | Doi | 10.1016/s0005-2736(96)00229-5 |
Citation | Suzuki F, et al. (1997) Cloning, functional expression and tissue distribution of rabbit alpha 1d-adrenoceptor. Biochim Biophys Acta 1323(1):6-11 |
abstractText | We have cloned a cDNA encoding rabbit alpha 1d-adrenoceptor from the rabbit liver cDNA library. The deduced amino-acid sequence of this clone encodes a protein of 576 amino acids that shows strong sequence homology to previously cloned human, rat and mouse alpha 1d-adrenoceptors. The pharmacological radioligand binding properties of this clone expressed in COS-7 cells were similar to those of rat alpha 1d-adrenoceptors. Competitive RT/PCR assays revealed wide tissue distribution of the alpha 1d-adrenoceptor mRNA in rabbit, especially abundant in vas deferens, aorta, prostate and cerebral cortex. |