| Primary Identifier | IPR033688 | Type | Family |
| Short Name | NAT10 |
| description | RNA cytidine acetyltransferase NAT10 has specificity toward both 18S rRNA and tRNAs and catalyzes the formation of N(4)-acetylcytidine at two positions in 18S rRNA. NAT10 is required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis [, ]. NAT10 also catalyzes the formation of N(4)-acetylcytidine at a single position in serine and leucine tRNAs. The tRNA-binding adapter protein TAN1 is required for full tRNA acetyltransferase activity but not for 18S rRNA acetylation [].Human NAT10 is a lysine acetyltransferase that targets microtubules and histones, and plays an important role in cell division. It is highly expressed in malignant tumors []. |
