| First Author | Whitmire JK | Year | 2007 |
| Journal | J Immunol | Volume | 179 |
| Issue | 2 | Pages | 1190-7 |
| PubMed ID | 17617612 | Mgi Jnum | J:149391 |
| Mgi Id | MGI:3848402 | Doi | 10.4049/jimmunol.179.2.1190 |
| Citation | Whitmire JK, et al. (2007) Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory. J Immunol 179(2):1190-7 |
| abstractText | Studies in IFN-gamma-deficient mice suggest that the delivery of IFN-gamma to CD8(+) T cells early in virus infection programs their eventual contraction, thereby reducing the abundance of CD8(+) memory T cells. In this study, we show that such mice fail to completely eliminate virus infection and that, when evaluated without the confounding factor of persisting Ag, both CD4(+) and CD8(+) T cells undergo profound contraction when they are unable to receive IFN-gamma signals. Furthermore, the abundance of CD4(+) and CD8(+) memory cells that express the IFN-gamma receptor is approximately 100-fold higher than cells lacking this molecule. Thus, direct IFN-gamma signaling is not required for T cell contraction during virus infection, and it enhances, rather than suppresses, the development of virus-specific CD4(+) and CD8(+) T cell memory. |
