| First Author | Lassi G | Year | 2016 |
| Journal | Genetics | Volume | 204 |
| Issue | 3 | Pages | 1129-1138 |
| PubMed ID | 27672097 | Mgi Jnum | J:242655 |
| Mgi Id | MGI:5905951 | Doi | 10.1534/genetics.116.192286 |
| Citation | Lassi G, et al. (2016) Working-for-Food Behaviors: A Preclinical Study in Prader-Willi Mutant Mice. Genetics 204(3):1129-1138 |
| abstractText | Abnormal feeding behavior is one of the main symptoms of Prader-Willi syndrome (PWS). By studying a PWS mouse mutant line, which carries a paternally inherited deletion of the small nucleolar RNA 116 (Snord116), we observed significant changes in working-for-food behavioral responses at various timescales. In particular, we report that PWS mutant mice show a significant delay compared to wild-type littermate controls in responding to both hour-scale and seconds-to-minutes-scale time intervals. This timing shift in mutant mice is associated with better performance in the working-for-food task, and results in better decision making in these mutant mice. The results of our study reveal a novel aspect of the organization of feeding behavior, and advance the understanding of the interplay between the metabolic functions and cognitive mechanisms of PWS. |
