| First Author | Bond CS | Year | 2009 |
| Journal | J Cell Biol | Volume | 186 |
| Issue | 5 | Pages | 637-44 |
| PubMed ID | 19720872 | Mgi Jnum | J:153837 |
| Mgi Id | MGI:4366394 | Doi | 10.1083/jcb.200906113 |
| Citation | Bond CS, et al. (2009) Paraspeckles: nuclear bodies built on long noncoding RNA. J Cell Biol 186(5):637-44 |
| abstractText | Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and PSPC1 [paraspeckle protein 1]) are members of the DBHS (Drosophila melanogaster behavior, human splicing) family. These proteins, together with the long nonprotein-coding RNA NEAT1 (MEN-epsilon/beta), associate to form paraspeckles and maintain their integrity. Given the large numbers of long noncoding transcripts currently being discovered through whole transcriptome analysis, paraspeckles may be a paradigm for a class of subnuclear bodies formed around long noncoding RNA. |
