| First Author | Herz J | Year | 1992 |
| Journal | Cell | Volume | 71 |
| Issue | 3 | Pages | 411-21 |
| PubMed ID | 1423604 | Mgi Jnum | J:30077 |
| Mgi Id | MGI:77595 | Doi | 10.1016/0092-8674(92)90511-a |
| Citation | Herz J, et al. (1992) LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation [published erratum appears in Cell 1993 May 7;73(3):428]. Cell 71(3):411-21 |
| abstractText | The low density lipoprotein receptor-related protein (LRP) is a large multifunctional clearance receptor that has been implicated in the hepatic uptake of chylomicron remnants and in the removal of protease-inhibitor complexes from the circulation and from the extracellular space. Disruption of the LRP gene in mice blocks development of LRP-/- embryos around the implantation stage. The expression pattern of LRP in the postimplantation stage embryo is identical to that of urokinase, a plasminogen activator that confers invasive properties to migrating cells. We demonstrate that LRP mediates uptake and degradation of urokinase-type plasminogen activator-plasminogen activator inhibitor 1 complexes and propose that the inability of the giant cells to remove the inactive protease complexes from their surfaces interferes with implantation of the embryo. |
