| First Author | Bovenschen N | Year | 2004 |
| Journal | Br J Haematol | Volume | 126 |
| Issue | 5 | Pages | 722-5 |
| PubMed ID | 15327526 | Mgi Jnum | J:109394 |
| Mgi Id | MGI:3628866 | Doi | 10.1111/j.1365-2141.2004.05093.x |
| Citation | Bovenschen N, et al. (2004) Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice. Br J Haematol 126(5):722-5 |
| abstractText | Low-density lipoprotein receptor-related protein (LRP) contributes to factor VIII (FVIII) catabolism in vivo. Besides LRP, FVIII also interacts with very low-density lipoprotein receptor (VLDLR) in vitro. We investigated the physiological role of VLDLR in FVIII catabolism, using knockout mouse models for VLDLR and LRP, alone and in combination. VLDLR(-/-) mice displayed normal plasma FVIII, whereas VLDLR(-/-) LRP(-) double-knockout mice had slightly increased FVIII compared with LRP-deficient mice. Remarkably, VLDLR deficiency slightly accelerated FVIII clearance. Adenovirus-mediated overexpression of VLDLR did not lower plasma FVIII in LRP-deficient mice. We conclude that VLDLR does not act in concert with LRP in FVIII clearance in vivo. |
