| First Author | Heikinheimo M | Year | 1994 |
| Journal | Dev Biol | Volume | 164 |
| Issue | 2 | Pages | 361-73 |
| PubMed ID | 8045339 | Mgi Jnum | J:19551 |
| Mgi Id | MGI:67722 | Doi | 10.1006/dbio.1994.1206 |
| Citation | Heikinheimo M, et al. (1994) Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev Biol 164(2):361-73 |
| abstractText | To clarify the role of transcription factor GATA-4 in mammalian development, we have determined the pattern of expression of GATA-4 in early postimplantation mouse embryos. Using in situ hybridization and immunohistochemistry, we find that GATA-4 RNA and protein are expressed in cells associated with heart development. Intraembryonic expression of GATA-4 RNA is first apparent in coelomic epithelial cells of the primitive streak embryo (approximately 7.0-7.5 days postcoitum). During formation and bending of the heart tube (approximately 8 days postcoitum), GATA-4 RNA and protein are expressed in endocardium, myocardium, and embryonic structures containing precardiac mesoderm such as the septum transversum and intraembryonic coelomic epithelium. By the onset of cardiac septation (approximately 9 days postcoitum), abundant GATA-4 RNA expression is evident in endocardium, endocardial cushion tissue, and myocardium. Expression of GATA-4 by the myocardium continues through gestation and after birth. The temporal and spacial patterns of GATA-4 expression support a role for this factor in the regulation of cardiac differentiation, analogous to the established role of transcription factor GATA-1 in the regulation of hematopoiesis. |
