| First Author | Cano E | Year | 1995 |
| Journal | Trends Biochem Sci | Volume | 20 |
| Issue | 3 | Pages | 117-22 |
| PubMed ID | 7709430 | Mgi Jnum | J:23595 |
| Mgi Id | MGI:71180 | Doi | 10.1016/s0968-0004(00)88978-1 |
| Citation | Cano E, et al. (1995) Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20(3):117-22 |
| abstractText | The intracellular signalling field is dominated by the mitogen-activated protein kinase (MAPK) cascade and its control, which involves the small GTPase Ras and sequential kinase activation. Until recently, ERK1 and ERK2 were the only cloned and well-characterized mammalian MAPKs; diverse ligand-stimulated, proline-directed protein phosphorylation events were attributed to these kinases. The recent discovery of two other MAPK subtypes, the JNK/SAPK subfamily and p38/RK (mammalian equivalents of HOG1 in yeast), reveals extreme complexity within the family and, most intriguingly, the existence in mammalian cells of parallel MAPK cascades that can be activated simultaneously. |
