| Primary Identifier | IPR030744 | Type | Family |
| Short Name | RasGRF2 |
| description | RasGRF2 belongs to the RasGRF family. It is a dual Ras/Rac guanine nucleotide exchange factor (GEF) that has been shown to be necessary for long-term potentiation in situ [, ]. It is also involved in T-cell signalling responses through Ras GTPases []. RasGRF2 has been linked to alcoholism [].RasGRF is a Ras family guanine nucleotide exchange factor sharing homology with Saccharomyces cerevisiae Cdc25 that stimulates nucleotide exchange on S. cerevisiae RAS []. RasGRF N-terminal region contains a Dbl homology (DH) domain which is generally present in GEFs for the Rho family of small G proteins, whereas the C-terminal Cdc25-related domain is linked to Ras GTPase signalling []. The presence of regulatory domains for Rho and Ras GTPases implicates the role of RasGRF in the control of the both pathways []. Two RasGRF, RasGRF1 and 2, have been identified in mammals []. Their function can be inhibited by its interaction with Cdc42 in its inactive GDP bound form. Reciprocally, the effects of Cdc42 on cytoskeletal dynamics can be inhibited by RasGRF1/2 []. |
