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Publication : Genomic structure and tissue distribution of the mouse dopamine D4 receptor.

First Author  Suzuki T Year  1995
Journal  Neurosci Lett Volume  199
Issue  1 Pages  69-72
PubMed ID  8584230 Mgi Jnum  J:30183
Mgi Id  MGI:77697 Doi  10.1016/0304-3940(95)12021-u
Citation  Suzuki T, et al. (1995) Genomic structure and tissue distribution of the mouse dopamine D4 receptor. Neurosci Lett 199(1):69-72
abstractText  The mouse dopamine D4 receptor gene was isolated from a genomic DNA library by plaque hybridization. The D4 receptor gene encoded an open reading frame consisting of 387 amino acids, interrupted by three introns. Distribution of the D4 receptor mRNA in brain regions and peripheral tissues of mice was examined by reverse transcription-polymerase chain reaction (RT-PCR). There was a remarkable expression of the receptor mRNA in various brain regions, showing the highest expression level in the cerebellum. Also, in the peripheral tissues a high level expression of the D4 mRNA was detected in the eye, adrenal gland and testes. We observed several differences in tissue distribution of the D4 mRNA in mice from that reported in other mammalian species.
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