| First Author | Sandstedt SA | Year | 2006 |
| Journal | Mamm Genome | Volume | 17 |
| Issue | 1 | Pages | 14-21 |
| PubMed ID | 16416087 | Mgi Jnum | J:104482 |
| Mgi Id | MGI:3612024 | Doi | 10.1007/s00335-005-0050-y |
| Citation | Sandstedt SA, et al. (2006) Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus. Mamm Genome 17(1):14-21 |
| abstractText | Two related genes with potentially similar functions, one on the Y chromosome and one on the X chromosome, were examined to determine if they evolved differently because of their chromosomal positions. Six hundred fifty-seven base pairs of coding sequence of Jarid1d (Smcy) on the Y chromosome and Jarid1c (Smcx) on the X chromosome were sequenced in 13 rodent taxa. An analysis of replacement and silent substitutions, using a counting method designed for samples with small evolutionary distances, showed a significant difference between the two genes. The different patterns of replacement and silent substitutions within Jarid1d and Jarid1c may be a result of evolutionary mechanisms that are particularly strong on the Y chromosome because of its unique properties. These findings are similar to results of previous studies of Y chromosomal genes in these and other mammalian taxa, suggesting that genes on the mammalian Y evolve in a chromosome-specific manner. |
