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Publication : Identification of a set of genes with developmentally down-regulated expression in the mouse brain.

First Author  Kumar S Year  1992
Journal  Biochem Biophys Res Commun Volume  185
Issue  3 Pages  1155-61
PubMed ID  1378265 Mgi Jnum  J:1344
Mgi Id  MGI:49871 Doi  10.1016/0006-291x(92)91747-e
Citation  Kumar S, et al. (1992) Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun 185(3):1155-61
abstractText  Using a subtraction cloning approach, we have isolated a set of cDNA clones from mouse neural precursor cells whose respective mRNA levels are down-regulated during the development of mouse brain. Single stranded DNA prepared from neuronal precursor cell cDNA library in lambda Zap vector was subtracted with poly (A)+ RNA prepared from postnatal and adult mouse brain to obtain several clones which show developmental down-regulation of expression. Their patterns of expression indicate that these genes may play important roles during the embryonic development and differentiation of central nervous system.
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