| First Author | Rauch SD | Year | 1987 |
| Journal | Mouse News Lett | Volume | 78 |
| Pages | 44 | Mgi Jnum | J:14995 |
| Mgi Id | MGI:63141 | Citation | Rauch SD (1987) Hereditary deafness of central origin in two new alleles of the quivering mutation. Mouse News Lett 78:44 |
| abstractText | Full text of MNL contribution: Research News: 2, Hereditary Deafness Central Origin in Two New Alleles of the Quivering Mutation. Quivering (qv), an autosomal recessive mutation, has been described by Deol et al. (Brain Res. 258: 177-179, 1985) as the first example of genetic deafness of central origin in animals. Evoked potential recordings and autoradiographic studies by Horner and Bock (Brain Res. 331: 217-223, 1985) point to the region of the cochlear nucleus as the site of the auditory lesion. Two new alleles, qv2J and qv3J, have been discovered at the Jackson Laboratory, Bar Harbor, Maine, in the CXB/J and C57BL/6J strains, respectively. In this study, recordings of brainstem auditory evoked potentials were obtained, in response to freefield rarefaction clicks generated by 30 usec electrical pulses at a rate of 30/sec, in qv2J/qv2J and qv3J/qv3J mice, and normal littermate controls. Findings of normal P1 threshold and latency in all animals, and absent or dysmorphic and delayed P2-P5 waves in mutant animals provide corroborative evidence of a lesion in the region of the cochlear nucleus in these two new alleles. (S.D. Rauch, Massachusetts Eye and Ear Infirmary). |
