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Publication : The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis.

First Author  Sonnenberg-Riethmacher E Year  1996
Journal  Genes Dev Volume  10
Issue  10 Pages  1184-93
PubMed ID  8675006 Mgi Jnum  J:33259
Mgi Id  MGI:80739 Doi  10.1101/gad.10.10.1184
Citation  Sonnenberg-Riethmacher E, et al. (1996) The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. Genes Dev 10(10):1184-93
abstractText  The c-ros gene was originally identified in mutant form as an oncogene. The proto-oncogene encodes a tyrosine kinase receptor that is expressed in a small number of epithelial cell types, including those of the epididymis. Targeted mutations of c-ros in the mouse reveal an essential role of the gene in male fertility. Male c-ros -/- animals do not reproduce, whereas the fertility of female animals is not affected. We demonstrate that c-ros is not required in a cell autonomous manner for male germ cell development or function. The gene, therefore, does not affect sperm generation or function in a direct manner. The primary defect in the mutant animals was located in the epididymis, showing that c-ros controls appropriate development of the epithelia, particularly regionalization and terminal differentiation. The epididymal defect does not interfere with production or storage of sperm but, rather, with sperm maturation and the ability of sperm to fertilize in vivo. Interestingly, sperm isolated from c-ros -/- animals can fertilize in vitro. Our results highlight the essential role of the epididymis in male fertility and demonstrate a highly specific function of the c-ros receptor tyrosine kinase during development of distinct epithelial cells.
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