| First Author | Han S | Year | 2014 |
| Journal | Mol Cells | Volume | 37 |
| Issue | 1 | Pages | 24-30 |
| PubMed ID | 24552706 | Mgi Jnum | J:279683 |
| Mgi Id | MGI:6363822 | Doi | 10.14348/molcells.2014.2206 |
| Citation | Han S, et al. (2014) Impaired extinction of learned contextual fear memory in early growth response 1 knockout mice. Mol Cells 37(1):24-30 |
| abstractText | Inductive expression of early growth response 1 (Egr-1) in neurons is associated with many forms of neuronal activity. However, only a few Egr-1 target genes are known in the brain. The results of this study demonstrate that Egr-1 knockout (KO) mice display impaired contextual extinction learning and normal fear acquisition relative to wild-type (WT) control animals. Genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of Egr-1 WT exposed to different phases of a fear conditioning paradigm compared to gene expression profiles in the hippocampus of KO mice. Some of genes, such as serotonin receptor 2C (Htr2c), neuropeptide B (Npb), neuronal PAS domain protein 4 (Npas4), NPY receptor Y1 (Npy1r), fatty acid binding protein 7 (Fabp7), and neuropeptide Y (Npy) are known to regulate processing of fearful memories, and promoter analyses demonstrated that several of these genes contained Egr-1 binding sites. This study provides a useful list of potential Egr-1 target genes which may be regulated during fear memory processing. |
