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Publication : Characterization of a Drosophila melanogaster orthologue of muskelin.

First Author  Adams JC Year  2002
Journal  Gene Volume  297
Issue  1-2 Pages  69-78
PubMed ID  12384287 Mgi Jnum  J:79960
Mgi Id  MGI:2429336 Doi  10.1016/s0378-1119(02)00887-9
Citation  Adams JC (2002) Characterization of a Drosophila melanogaster orthologue of muskelin. Gene 297(1-2):69-78
abstractText  Muskelin was identified in vertebrates as a novel, intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1. The identification and characterization of an orthologue of muskelin in Drosophila melanogaster is now reported. The Drosophila muskelin gene, located on chromosome 2R, is encoded in ten exons. Drosophila muskelin is expressed in embryos, larvae and adult flies. The protein has 45% sequence identity to vertebrate muskelins, with highest sequence identity in an amino-terminal domain and the six kelch repeats that form a beta-propeller structure. Multiple sequence alignment of human, mouse, rat and Drosophila muskelins and protein database searches revealed a novel highly conserved motif within the amino-terminal domain, lissencephaly homology motif (LisH) and C-terminal to LisH motifs in the central region of the molecule, and several conserved consensus motifs for phosphorylation by protein kinase C and casein kinase II. These findings provide new information on the modular structure of muskelin and indicate potential for conserved mechanisms of function.
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