| Primary Identifier | MGI:107689 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 16568 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables intraciliary transport particle B binding activity and microtubule binding activity. Involved in several processes, including alpha-tubulin acetylation; anterograde dendritic transport of neurotransmitter receptor complex; and microtubule cytoskeleton organization. Acts upstream of or within several processes, including chordate embryonic development; plasma membrane bounded cell projection organization; and regionalization. Located in centriole; motile cilium; and photoreceptor connecting cilium. Part of kinesin II complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including gonad; liver; nervous system; node; and spleen. Used to study dysostosis; polycystic kidney disease; and polycystic kidney disease 1. Orthologous to human KIF3A (kinesin family member 3A). PHENOTYPE: Nullizygous mutations result in embryonic lethality, failure to synthesize cilia in the embryonic node, randomization of left-right asymmetry and structural abnormalities of the neural tube, pericardium, branchial arches, and somites. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
