| First Author | Smithies O | Year | 1985 |
| Journal | Nature | Volume | 317 |
| Issue | 6034 | Pages | 230-4 |
| PubMed ID | 2995814 | Mgi Jnum | J:141518 |
| Mgi Id | MGI:3818416 | Doi | 10.1038/317230a0 |
| Citation | Smithies O, et al. (1985) Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature 317(6034):230-4 |
| abstractText | A 'rescuable' plasmid containing globin gene sequences allowing recombination with homologous chromosomal sequences has enabled us to produce, score and clone mammalian cells with the plasmid integrated into the human beta-globin locus. The planned modification was achieved in about one per thousand transformed cells whether or not the target gene was expressed. |
