| First Author | Nie Y | Year | 2004 |
| Journal | J Exp Med | Volume | 200 |
| Issue | 9 | Pages | 1145-56 |
| PubMed ID | 15520246 | Mgi Jnum | J:94911 |
| Mgi Id | MGI:3522074 | Doi | 10.1084/jem.20041185 |
| Citation | Nie Y, et al. (2004) The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med 200(9):1145-56 |
| abstractText | The chemokine receptor CXCR4 is expressed in B cells at multiple stages of their development. CXCR4 function in humoral immunity has not been fully investigated. We have generated gene-targeted mice in which CXCR4 can be selectively inactivated in B cells and have shown that it is required for retention of B cell precursors in the bone marrow. CXCR4-deficient B cell precursors that migrated prematurely became localized in splenic follicles despite their unresponsiveness to CXCL13. Concomitantly, mature B cell populations were reduced in the splenic marginal zone and primary follicles, and in the peritoneal cavity in the mutant animals, as were T-independent antibody responses. In addition, aberrant B cell follicles formed ectopically in intestinal lamina propria around Peyer's patches. These findings establish an important role for CXCR4 in regulating homeostasis of B cell compartmentalization and humoral immunity. |
