| Primary Identifier | MGI:2442572 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 106504 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Predicted to be involved in intracellular signal transduction; postsynapse organization; and protein modification process. Predicted to be located in cytosol and nucleus. Predicted to be active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and nose. Orthologous to human STK38 (serine/threonine kinase 38). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection and altered TLR9-activated inflammatory responses. Mice homozygous for a different knock-out allele exhibit mislocalization of opsin, increased apoptosis and proliferation of photoreceptors in the inner nuclear layer and disrupted localization of amacrine cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
