| First Author | Stowell SR | Year | 2013 |
| Journal | J Immunol | Volume | 191 |
| Issue | 10 | Pages | 5013-25 |
| PubMed ID | 24108700 | Mgi Jnum | J:206332 |
| Mgi Id | MGI:5550034 | Doi | 10.4049/jimmunol.1300885 |
| Citation | Stowell SR, et al. (2013) Antigen modulation confers protection to red blood cells from antibody through Fcgamma receptor ligation. J Immunol 191(10):5013-25 |
| abstractText | Autoantibodies and alloantibodies can damage self-tissue or transplanted tissues through either fixation of complement or ligation of FcgammaRs. Several pathways have been described that imbue self-tissues with resistance to damage from complement fixation, as a protective measure against damage from these Abs. However, it has been unclear whether parallel pathways exist to provide protection from FcgammaR ligation by bound Abs. In this article, we describe a novel pathway by which cell surface Ag is specifically decreased as a result of Ab binding (Ag modulation) to the extent of conferring protection to recognized cells from Fcgamma-dependent clearance. Moreover, the Ag modulation in this system requires FcgammaR ligation. Together, these findings provide unique evidence of self-protective pathways for FcgammaR-mediated Ab damage. |
