Primary Identifier | MGI:2447810 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 353258 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to be involved in ribosomal small subunit biogenesis and ribosomal small subunit export from nucleus. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in nucleoplasm. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including cerebral cortex; limb digit; nose; oocyte; and skeleton. Human ortholog(s) of this gene implicated in inflammatory poikiloderma with hair abnormalities and acral keratoses. Orthologous to human LTV1 (LTV1 ribosome biogenesis factor). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and form blastocysts. [provided by MGI curators] |