| First Author | Murray IR | Year | 2017 |
| Journal | Nat Commun | Volume | 8 |
| Issue | 1 | Pages | 1118 |
| PubMed ID | 29061963 | Mgi Jnum | J:252731 |
| Mgi Id | MGI:6099137 | Doi | 10.1038/s41467-017-01097-z |
| Citation | Murray IR, et al. (2017) alphav integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis. Nat Commun 8(1):1118 |
| abstractText | Mesenchymal cells expressing platelet-derived growth factor receptor beta (PDGFRbeta) are known to be important in fibrosis of organs such as the liver and kidney. Here we show that PDGFRbeta(+) cells contribute to skeletal muscle and cardiac fibrosis via a mechanism that depends on alphav integrins. Mice in which alphav integrin is depleted in PDGFRbeta(+) cells are protected from cardiotoxin and laceration-induced skeletal muscle fibrosis and angiotensin II-induced cardiac fibrosis. In addition, a small-molecule inhibitor of alphav integrins attenuates fibrosis, even when pre-established, in both skeletal and cardiac muscle, and improves skeletal muscle function. alphav integrin blockade also reduces TGFbeta activation in primary human skeletal muscle and cardiac PDGFRbeta(+) cells, suggesting that alphav integrin inhibitors may be effective for the treatment and prevention of a broad range of muscle fibroses. |
