| First Author | Sims MA | Year | 2000 |
| Journal | Cytogenet Cell Genet | Volume | 89 |
| Issue | 3-4 | Pages | 268-71 |
| PubMed ID | 10965141 | Mgi Jnum | J:175362 |
| Mgi Id | MGI:5285181 | Doi | 10.1159/000015631 |
| Citation | Sims MA, et al. (2000) Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. Cytogenet Cell Genet 89(3-4):268-71 |
| abstractText | The integrin family of receptors serves as major receptors for extracellular matrix-mediated cell adhesion and migration, cytoskeletal organisation, cell proliferation, survival, and differentiation. The alpha-V integrins consist of a subset which share a common alpha-V subunit combined with one of five beta subunits (beta-1, 3, 5, 6, or 8). The alpha-V integrins have been implicated in a number of developmental processes, including vasculogenesis and angiogenesis, and are therapeutic targets for inhibition of angiogenesis and osteoporosis. The human cDNA for alpha-V integrin (ITGAV) consists of a 5,717-bp transcript with a coding sequence (CDS) of 3,146 bp encoding a 150-kDa mature peptide. Here we describe the gene structure of ITGAV. |
