| First Author | Chuang LS | Year | 2013 |
| Journal | Int J Cancer | Volume | 132 |
| Issue | 6 | Pages | 1260-71 |
| PubMed ID | 23180629 | Mgi Jnum | J:193504 |
| Mgi Id | MGI:5468628 | Doi | 10.1002/ijc.27964 |
| Citation | Chuang LS, et al. (2013) RUNX family: Regulation and diversification of roles through interacting proteins. Int J Cancer 132(6):1260-71 |
| abstractText | The Runt-related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein-interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses. |
