Primary Identifier | MGI:2684949 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 214575 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in P granule organization; siRNA-mediated retrotransposon silencing by heterochromatin formation; and spermatid development. Located in chromatoid body and pi-body. Is active in synapse. Is expressed in genitourinary system. Orthologous to human TDRD5 (tudor domain containing 5). PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with defective spermatid elongation, occasional arrested male meiosis, and apoptosis of male germ cells. [provided by MGI curators] |