| Primary Identifier | MGI:1857813 | Allele Type | Transgenic |
| Gene | Edar | Inheritance Mode | Recessive |
| Strain of Origin | (C57BL/6 x C3H)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | Similar phenotypes have also been described in mice for the Tabby allelic series at the Eda locus. |
| molecularNote | A transgene containing a hybrid DNA construct, which includes the regulatory sequences of the mouse alpha-crystallin gene and the early region of SV40, inserted into the gene. A founder mouse from one microinjection event produced offspring carrying two different integration sites. The subsequent lines were called EdarTgN(OVE1A)Ove and EdarTgN(OVE1B)Ove. In both cases, integration was accompanied by a genomic deletion and an intrachromosomal inversion. The deletions were found to be overlapping. This allele is defined by a noncomplementation test with Edardl, and contains a 600 kb deletion. |
