Primary Identifier | MGI:3619352 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 723844 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in osteoblast differentiation; response to estrogen; and response to wounding. Acts upstream of or within several processes, including long-term synaptic potentiation; negative regulation of osteoblast differentiation; and sensory perception of sound. Part of RISC complex. Is expressed in brain; embryo; limb; lung; and neural crest. Orthologous to human MIR338 (microRNA 338). PHENOTYPE: Mice homozygous for a null allele exhibit incrased trabecular bone volume and thickness, decreased osteoclast cell number, and resistance to ovariectomy-induced osteoporosis. [provided by MGI curators] |