| First Author | Kos A | Year | 2017 |
| Journal | RNA Biol | Volume | 14 |
| Issue | 7 | Pages | 905-913 |
| PubMed ID | 28494198 | Mgi Jnum | J:321238 |
| Mgi Id | MGI:6881029 | Doi | 10.1080/15476286.2017.1325067 |
| Citation | Kos A, et al. (2017) MicroRNA-338 modulates cortical neuronal placement and polarity. RNA Biol 14(7):905-913 |
| abstractText | The precise spatial and temporal regulation of gene expression orchestrates the many intricate processes during brain development. In the present study we examined the role of the brain-enriched microRNA-338 (miR-338) during mouse cortical development. Reduction of miR-338 levels in the developing mouse cortex, using a sequence-specific miR-sponge, resulted in a loss of neuronal polarity in the cortical plate and significantly reduced the number of neurons within this cortical layer. Conversely, miR-338 overexpression in developing mouse cortex increased the number of neurons, which exhibited a multipolar morphology. All together, our results raise the possibility for a direct role for this non-coding RNA, which was recently associated with schizophrenia, in the regulation of cortical neuronal polarity and layer placement. |
