| First Author | Förster I | Year | 1995 |
| Journal | Immunity | Volume | 2 |
| Issue | 6 | Pages | 573-85 |
| PubMed ID | 7796292 | Mgi Jnum | J:81330 |
| Mgi Id | MGI:2448889 | Doi | 10.1016/1074-7613(95)90002-0 |
| Citation | Forster I, et al. (1995) Limited capacity for tolerization of CD4+ T cells specific for a pancreatic beta cell neo-antigen. Immunity 2(6):573-85 |
| abstractText | Mice transgenic for SV40 T antigen (Tag) under control of the rat insulin promoter (RIP) develop two alternative immunological phenotypes: tolerance or autoimmunity towards Tag. We utilized the T cell receptor (TCR) genes expressed in a Tag-specific CD4+ cell from an autoimmune RIP-Tag mouse to generate two lines of TCR transgenic mice in which either 10% or 90% of peripheral T cells express the transgenic TCR. When cross-bred to the tolerant RIP1-Tag2 line, mice from the low frequency TCR line showed partial deletion of peripheral Tag-specific T cells and nonresponsiveness of those that remained. In contrast, crossbred mice in which transgenic T cells comprised a majority of the T cell population were nontolerant both in vivo and in vitro. Thus, tolerization of CD4+ T cells specific for a rare self-antigen may fail if too many autoreactive T cells develop. |
