| First Author | Wada S | Year | 2011 |
| Journal | J Biol Chem | Volume | 286 |
| Issue | 44 | Pages | 38456-65 |
| PubMed ID | 21926429 | Mgi Jnum | J:178161 |
| Mgi Id | MGI:5297631 | Doi | 10.1074/jbc.M111.271270 |
| Citation | Wada S, et al. (2011) Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy. J Biol Chem 286(44):38456-65 |
| abstractText | Muscle atrophy is caused by accelerated protein degradation and occurs in many pathological states. Two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and muscle RING-finger 1 (MuRF1), are prominently induced during muscle atrophy and mediate atrophy-associated protein degradation. Blocking the expression of these two ubiquitin ligases provides protection against muscle atrophy. Here we report that miR-23a suppresses the translation of both MAFbx/atrogin-1 and MuRF1 in a 3'-UTR-dependent manner. Ectopic expression of miR-23a is sufficient to protect muscles from atrophy in vitro and in vivo. Furthermore, miR-23a transgenic mice showed resistance against glucocorticoid-induced skeletal muscle atrophy. These data suggest that suppression of multiple regulators by a single miRNA can have significant consequences in adult tissues. |
