| First Author | Yang Y | Year | 1996 |
| Journal | Cell | Volume | 86 |
| Issue | 4 | Pages | 655-65 |
| PubMed ID | 8752219 | Mgi Jnum | J:35022 |
| Mgi Id | MGI:82474 | Doi | 10.1016/s0092-8674(00)80138-5 |
| Citation | Yang Y, et al. (1996) An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell 86(4):655-65 |
| abstractText | Typified by rapid degeneration of sensory neurons, dystonia musculorum mice have a defective BPAG1 gene, known to be expressed in epidermis. We report a neuronal splice form, BPAG1n, which localizes to sensory axons. Both isoforms have a coiled-coil rod, followed by a carboxy domain that associates with intermediate filaments. However, the amino terminus of BPAG1n differs from BPAG1e in that it contains a functional actin-binding domain. In transfected cells, BPAG1n coaligns neurofilaments and microfilaments, establishing this as a cytoskeletal protein interconnecting actin and intermediate filament cytoskeletons. In BPAG1 null mice, axonal architecture is markedly perturbed, consistent with a failure to tether neurofilaments to the actin cytoskeleton and underscoring the physiological relevance of this protein. |
