| First Author | Mallamaci A | Year | 1998 |
| Journal | Mech Dev | Volume | 77 |
| Issue | 2 | Pages | 165-72 |
| PubMed ID | 9831645 | Mgi Jnum | J:51432 |
| Mgi Id | MGI:1316614 | Doi | 10.1016/s0925-4773(98)00141-5 |
| Citation | Mallamaci A, et al. (1998) EMX2 protein in the developing mouse brain and olfactory area. Mech Dev 77(2):165-72 |
| abstractText | The distribution of EMX2, the protein product of the homeobox gene Emx2, was analyzed in the developing mouse CNS by means of a polyclonal antibody we raised against it. The protein is present in the rostral brain, the olfactory area and a set of scattered cells lying between the nasal pits and the telencephalon. In the cortical neuroepithelium EMX2 is expressed all along the rostro-caudal axis in a graded distribution with a caudal-medial maximum and a rostral-lateral minimum. Anti-EMX2 immunoreactivity is also detectable in Cajal-Retzius cells as well as in apical dendrites of marginal neurons of the cortical plate. We also observe that the EMX2 and EMX1 homeoproteins display complementary expression patterns in olfactory bulbs and amygdaloid complex. Here, they demarcate different neuronal populations, involved in processing olfactory information coming from the vomero-nasal organ and from the main olfactory epithelium, respectively. EMX2 is also detectable in mesencephalic structures, such as the optic tectum and tegmentum. The graded distribution of EMX2 along antero-posterior and medial-lateral axes of the primitive cortex prefigures a role of this protein in the subdivision of the cortex in cytoarchitectonic regions and possibly functional areas, whereas its presence in Cajal-Retzius cells suggests a role in the process of cortical lamination. Copyright 1998 Elsevier Science Ireland Ltd. All Rights Reserved |
