Primary Identifier | MGI:1289247 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 74775 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable transmembrane signaling receptor activity. Involved in several processes, including T cell activation; hematopoietic stem cell differentiation; and negative regulation of canonical Wnt signaling pathway. Located in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LMBR1L (limb development membrane protein 1 like). PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit altered lymphopoiesis and lymphoid activation. [provided by MGI curators] |