| First Author | Gu C | Year | 2005 |
| Journal | Science | Volume | 307 |
| Issue | 5707 | Pages | 265-8 |
| PubMed ID | 15550623 | Mgi Jnum | J:95697 |
| Mgi Id | MGI:3526793 | Doi | 10.1126/science.1105416 |
| Citation | Gu C, et al. (2005) Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science 307(5707):265-8 |
| abstractText | The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning and the patterning of the developing vasculature in the mouse. Sema3E is highly expressed in developing somites, where it acts as a repulsive cue for plexin-D1-expressing endothelial cells of adjacent intersomitic vessels. Sema3E-plexin-D1 signaling did not require neuropilins, which were previously presumed to be obligate Sema3 coreceptors. Moreover, genetic ablation of Sema3E or plexin-D1 but not neuropilin-mediated Sema3 signaling disrupted vascular patterning. These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning. |
