| Primary Identifier | MGI:88354 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 12550 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and identical protein binding activity. Involved in several processes, including decidualization; embryo implantation; and uterine epithelium development. Acts upstream of or within several processes, including epithelial cell development; regulation of protein localization; and regulation of proteolysis. Located in several cellular components, including Schmidt-Lanterman incisure; axon; and basolateral plasma membrane. Part of catenin complex and flotillin complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study invasive lobular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple). Orthologous to human CDH1 (cadherin 1). PHENOTYPE: In mutant homozygotes, adhesive cells of the morula dissociate shortly after initial compaction, probably due to depletion of maternal protein. Mutant embryos fail to form a trophectodermal epithelium or blastocyst cavity, and die near implantation time. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
