| Primary Identifier | MGI:2387609 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 224807 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium-activated cation channel activity; mechanosensitive monoatomic ion channel activity; and osmolarity-sensing monoatomic cation channel activity. Involved in sensory perception of sound and surfactant secretion. Located in plasma membrane. Is expressed in jaw bone; nervous system; and sensory organ. Orthologous to human TMEM63B (transmembrane protein 63B). PHENOTYPE: Mice homozygous for a null allele exhibit progressive hearing loss leading to deafness, with cochlear outer hair cell necroptosis, degeneration and impaired hypo-osmolarity-activated currents. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
