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Publication : FoxOs in tumor suppression and stem cell maintenance.

First Author  Arden KC Year  2007
Journal  Cell Volume  128
Issue  2 Pages  235-7
PubMed ID  17254960 Mgi Jnum  J:117882
Mgi Id  MGI:3697949 Doi  10.1016/j.cell.2007.01.009
Citation  Arden KC (2007) FoxOs in tumor suppression and stem cell maintenance. Cell 128(2):235-7
abstractText  The FoxO transcription factors have been implicated in many processes including tumor suppression and cell death. In this issue, two groups now report on mice that conditionally lack the three predominant FoxO transcription factors. Demonstrate that FoxOs are critical for the long-term maintenance of hematopoietic stem cells, and show that FoxOs suppress the formation of hemangiomas and lymphomas in mice.
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