| First Author | Palazon A | Year | 2017 |
| Journal | Cancer Cell | Volume | 32 |
| Issue | 5 | Pages | 669-683.e5 |
| PubMed ID | 29136509 | Mgi Jnum | J:248840 |
| Mgi Id | MGI:6093877 | Doi | 10.1016/j.ccell.2017.10.003 |
| Citation | Palazon A, et al. (2017) An HIF-1alpha/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression. Cancer Cell 32(5):669-683.e5 |
| abstractText | Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1alpha, but not HIF-2alpha, was essential for the effector state in CD8(+) T cells. Furthermore, loss of HIF-1alpha in CD8(+) T cells reduced tumor infiltration and tumor cell killing, and altered tumor vascularization. Deletion of VEGF-A, an HIF target gene, in CD8(+) T cells accelerated tumorigenesis while also altering vascularization. Analyses of human breast cancer showed inverse correlations between VEGF-A expression and CD8(+) T cell infiltration, and a link between T cell infiltration and vascularization. These data demonstrate that the HIF-1alpha/VEGF-A axis is an essential aspect of tumor immunity. |
