| First Author | Giese KP | Year | 2001 |
| Journal | Neuropharmacology | Volume | 41 |
| Issue | 6 | Pages | 791-800 |
| PubMed ID | 11640934 | Mgi Jnum | J:91065 |
| Mgi Id | MGI:3045888 | Doi | 10.1016/s0028-3908(01)00096-x |
| Citation | Giese KP, et al. (2001) Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology 41(6):791-800 |
| abstractText | Previous results have suggested that the Ras signaling pathway is involved in learning and memory. Ras is activated by nucleotide exchange factors, such as the calmodulin-activated guanine-nucleotide releasing factor 1 (Ras-GRF1). To test whether Ras-GRF1 is required for learning and memory, we inactivated the Ras-GRF1 gene in mice. These mutants performed normally in a rota-rod motor coordination task, and in two amygdala-dependent tasks (inhibitory avoidance and contextual conditioning). In contrast the mutants were impaired in three hippocampus-dependent learning tasks: contextual discrimination, the social transmission of food preferences, and the hidden-platform version of the Morris water maze. These studies indicate that Ras-GRF1 plays a role in hippocampal-dependent learning and memory. |
