| Primary Identifier | IPR044281 | Type | Family |
| Short Name | IMP4/RPF1 |
| description | This family represents the U3 small nucleolar ribonucleoprotein protein IMP4 and Ribosome production factor 1 RPF1 that belong to the IMP4 superfamily. This superfamily contains a Brix (biogenesis of ribosomes in Xenopus) domain, a region of 150-180 residues length, and it is characterised by the sigma70-like motif, a sequence motif first identified in the sigma70 family of prokaryotic transcription factors, which is sufficient to confer RNA binding activity [, , ]. IMP4 is a component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) and it is required for the early cleavages during pre-18S ribosomal RNA processing [, ]. RPF1 is a essential protein involved in ribosome biogenesis []. |
