| Type | disruption phenotype | Description | Mice lacking all isoforms encoded by both Schip1 and Iqcj-Schip1 are fertile and survive as long as wild-type mice. However, they exhibit mild growth delay associated with ataxia and reduced pain sensitivity. They display decreased thickness of the piriform cortex and partial agenesis of the anterior comissure which could be due to impaired axon elongation and guidance. The morphology of nodes of Ranvier is affected but nerves do not exhibit significant electrophysiological characteristic differences. A reduction in the number of axonal projections in the peripheral nerve system is also observed. |
