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Protein Coding Gene : Brip1 BRCA1 interacting protein C-terminal helicase 1
Primary Identifier  MGI:2442836 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  237911
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable 5'-3' DNA helicase activity and chromatin binding activity. Acts upstream of or within reciprocal meiotic recombination; seminiferous tubule development; and spermatogenesis. Predicted to be located in cytoplasm; nuclear membrane; and nucleoplasm. Predicted to be part of BRCA1-B complex. Predicted to be active in nucleus. Is expressed in brain and cochlea. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group J; breast cancer; colorectal cancer; and thrombocytopenia. Orthologous to human BRIP1 (BRCA1 interacting helicase 1).
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit gonadal atrophy, subfertility, germ cell attrition, epithelial tumor predisposition, increased cellular sensitivity to interstrand crosslink-inducing agents, hypersensitivity to replication inhibitors, and predisposition to lymphoma. [provided by MGI curators]
  • synonyms:
  • MGI:1920358,
  • BACH1,
  • Brip1,
  • 8030460J03Rik,
  • RIKEN cDNA 3110009N10 gene,
  • BRCA1 interacting protein C-terminal helicase 1,
  • RIKEN cDNA 8030460J03 gene,
  • 3110009N10Rik
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2 Involved In Mutations

Trail: ProteinCodingGene

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21 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

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Mouse features --> Human diseases

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