| First Author | Huang GN | Year | 2012 |
| Journal | Science | Volume | 338 |
| Issue | 6114 | Pages | 1599-603 |
| PubMed ID | 23160954 | Mgi Jnum | J:191205 |
| Mgi Id | MGI:5461250 | Doi | 10.1126/science.1229765 |
| Citation | Huang GN, et al. (2012) C/EBP transcription factors mediate epicardial activation during heart development and injury. Science 338(6114):1599-603 |
| abstractText | The epicardium encapsulates the heart and functions as a source of multipotent progenitor cells and paracrine factors essential for cardiac development and repair. Injury of the adult heart results in reactivation of a developmental gene program in the epicardium, but the transcriptional basis of epicardial gene expression has not been delineated. We established a mouse embryonic heart organ culture and gene expression system that facilitated the identification of epicardial enhancers activated during heart development and injury. Epicardial activation of these enhancers depends on a combinatorial transcriptional code centered on CCAAT/enhancer binding protein (C/EBP) transcription factors. Disruption of C/EBP signaling in the adult epicardium reduced injury-induced neutrophil infiltration and improved cardiac function. These findings reveal a transcriptional basis for epicardial activation and heart injury, providing a platform for enhancing cardiac regeneration. |
