| First Author | Okamura D | Year | 2012 |
| Journal | Genes Dev | Volume | 26 |
| Issue | 22 | Pages | 2477-82 |
| PubMed ID | 23154982 | Mgi Jnum | J:191206 |
| Mgi Id | MGI:5461251 | Doi | 10.1101/gad.202242.112 |
| Citation | Okamura D, et al. (2012) Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev 26(22):2477-82 |
| abstractText | Transcription elongation is stimulated by positive transcription elongation factor b (P-TEFb), for which activity is repressed in the 7SK small nuclear ribonucleoprotein (7SK snRNP) complex. We show here a critical role of 7SK snRNP in growth control of primordial germ cells (PGCs). The expression of p15(INK4b), a cyclin-dependent kinase inhibitor (CDKI) gene, in PGCs is selectively activated by P-TEFb and its recruiting molecule, Brd4, when the amount of active P-TEFb is increased due to reduction of the 7SK snRNP, and PGCs consequently undergo growth arrest. These results indicate that CDKI gene-specific control of transcription by 7SK snRNP plays a pivotal role in the maintenance of PGC proliferation. |
